Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type Study_count
Total_Studies 1351
interventional 1197
Observational 144
Registry 10

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 371
Drug|placebo 334
Behavioral 158
Device 129
Other 53
Behavioral|Drug 22
Behavioral|Other 14
Dietary Supplement 10
Drug|Other 9
Dietary Supplement|placebo 8
Drug|Procedure 8
Procedure 8
Behavioral|Device 7
Device|Drug|placebo 6
Device|Drug 4
Device|Other 4
Drug|Other|placebo 4
Behavioral|Drug|Other 3
Biological 3
Dietary Supplement|Drug 3
Genetic|Other 3
Behavioral|Device|Drug 2
Behavioral|Drug|placebo 2
Behavioral|Drug|Procedure 2
Biological|placebo 2
Device|Procedure 2
Diagnostic Test|Other 2
Drug|Genetic 2
Drug|placebo|Procedure 2
Genetic 2
Behavioral|Device|Drug|Radiation 1
Behavioral|Device|Other 1
Behavioral|Diagnostic Test|Other 1
Behavioral|Other|Radiation 1
Biological|Drug 1
Combination Product 1
Combination Product|Drug|Other 1
Combination Product|Other 1
Combination Product|placebo 1
Device|Drug|Other|placebo 1
Device|placebo 1
Diagnostic Test 1
Diagnostic Test|Drug|placebo 1
Dietary Supplement|Drug|Other 1
Other|placebo 1
Other|Procedure 1
placebo 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country Study_Count
United States 573
Canada 87
NA 83
China 37
Germany 35
Japan 26
France 18
Taiwan 18
United Kingdom 18
United States|Canada 16
Israel 15
Korea, Republic of 14
Denmark 11
United States|Puerto Rico 11
Brazil 10
Australia 9
Spain 8
Sweden 8
Switzerland 8
Belgium 7
Hong Kong 6
Netherlands 6
Norway 6
Egypt 4
Austria 3
India 3
Germany|Netherlands 2
Iran, Islamic Republic of 2
Italy 2
Japan|Korea, Republic of 2
Pakistan 2
Poland 2
Portugal 2
United States|Australia 2
United States|Bulgaria|Canada|Colombia|Estonia|France|Germany|Hungary|Israel|Italy|Korea, Republic of|Latvia|Mexico|Poland|Russian Federation|Serbia|South Africa|Spain|Ukraine|United Kingdom 2
United States|China 2
United States|India 2
United States|Israel 2
United States|Mexico 2
Argentina|Belgium|Chile|Costa Rica|Germany|Italy|Peru|Poland|Slovakia|Spain|Sweden 1
Argentina|Brazil|Bulgaria|Chile|Colombia|Croatia|France|Germany|Hungary|Poland|Romania|Russian Federation|Serbia|Slovakia|South Africa|Spain|Ukraine 1
Argentina|Bulgaria|Canada|Chile|Croatia|Mexico|Russian Federation 1
Argentina|Bulgaria|Croatia|Czech Republic|Finland|France|Mexico|Poland|Romania|Russian Federation|Serbia|Slovakia|South Africa 1
Argentina|Chile|Greece|Hong Kong|Morocco|Russian Federation|Singapore|South Africa|Spain|Taiwan|Tunisia 1
Australia|Belgium|Canada|Czech Republic|Finland|France|Germany|Norway|Poland|Romania|South Africa|Sweden 1
Australia|Belgium|Finland|Netherlands|Norway|Russian Federation 1
Australia|Canada 1
Australia|Canada|Mexico|Russian Federation|Taiwan 1
Australia|Czech Republic|France|Germany|Korea, Republic of|Latvia|Lithuania|Malaysia|Netherlands|Poland|Russian Federation|South Africa|Taiwan|Ukraine|United Kingdom 1
Australia|Japan|Korea, Republic of|Malaysia|Taiwan 1
Australia|Turkey 1
Austria|Croatia|France|Hungary|Poland|Romania|Russian Federation|Serbia|Ukraine|United Kingdom 1
Austria|Czech Republic|Germany 1
Austria|Czech Republic|Italy|Romania|Slovakia|Spain 1
Austria|Russian Federation 1
Bangladesh 1
Belgium|Czech Republic|Finland|France|Germany|Slovakia 1
Belgium|Estonia|Finland|France|Germany|Greece|India|Korea, Republic of|Malaysia|Morocco|Taiwan|Tunisia|Turkey 1
Belgium|Germany|Netherlands 1
Belgium|Germany|Poland 1
Bulgaria|Croatia|Czech Republic|Estonia|France|Montenegro|Netherlands|Serbia 1
Bulgaria|Croatia|Former Serbia and Montenegro|Romania 1
Bulgaria|Croatia|Romania|Serbia 1
Bulgaria|Czechia|Finland|Hungary|Russian Federation|Slovakia|Ukraine 1
Bulgaria|Estonia|France|Germany|Hungary|Italy|Latvia|Poland|Russian Federation|Serbia|South Africa|Spain|United Kingdom 1
Bulgaria|Estonia|Latvia 1
Bulgaria|Hungary|Moldova, Republic of|Romania|Russian Federation|Ukraine 1
Bulgaria|United States|Finland|Germany|Poland|Russian Federation|Ukraine 1
Chile 1
Chile|Mexico|Romania|Russian Federation|Slovakia|South Africa|Ukraine 1
China|Hong Kong 1
Croatia 1
Croatia|Estonia|Finland|France|Latvia|Lithuania|Poland|Romania|Slovakia|South Africa 1
Croatia|Finland|Germany|Hong Kong|India|Japan|Korea, Republic of|Latvia|Malaysia|Philippines|Poland|Romania|Russian Federation|Serbia|Taiwan|Ukraine 1
Czech Republic|Estonia|Finland|France|Germany|Hungary|Latvia|Lithuania|Poland|Sweden 1
Czechia 1
Denmark|France|Greece|Hungary|Italy|Netherlands|Romania|Slovenia|Spain|Sweden|Turkey 1
Estonia 1
Estonia|Finland 1
Estonia|Finland|Germany|Lithuania 1
Estonia|Finland|Germany|Serbia|Slovakia 1
Estonia|France|Italy|Korea, Republic of|Poland|Spain 1
Estonia|Russian Federation 1
Ethiopia 1
Finland 1
Finland|Germany|Serbia|Slovakia 1
Finland|Poland|Russian Federation|Serbia|Slovakia|South Africa|Ukraine|United Kingdom 1
Finland|United States|Bulgaria|France|Germany|Japan|Russian Federation|Ukraine 1
France|Ireland|Spain|United Kingdom 1
France|Israel|United Kingdom 1
France|Italy|Lithuania|Spain 1
France|Italy|Russian Federation|South Africa 1
Germany|Australia|Austria|Belgium|Bulgaria|Denmark|Hungary|Italy|Portugal|Romania|Slovakia|Spain|United Kingdom 1
Germany|Poland|Russian Federation|United States|Canada|France|Serbia 1
India|China|Korea, Republic of|Taiwan 1
Mexico 1
Mexico|Canada|China|Finland|Korea, Republic of|Malaysia|Philippines|South Africa|Spain 1
Romania 1
Russian Federation 1
Russian Federation|Belgium|Canada|Chile|Estonia|Finland|France|Germany|Netherlands|Slovakia|South Africa|Sweden 1
Russian Federation|United States|Bulgaria|Canada|Colombia|Estonia|France|Germany|Hungary|Italy|Korea, Republic of|Latvia|Mexico|Poland|Serbia|South Africa|Spain|Ukraine|United Kingdom 1
Sweden|Australia|Austria|Belgium|Canada|Czech Republic|Finland|France|India|Korea, Republic of|Lithuania|Malaysia|Norway|Philippines|Russian Federation|Serbia|Ukraine 1
Turkey 1
Ukraine 1
Ukraine|United States|Austria|Canada|Germany|Russian Federation|Slovakia|South Africa 1
United States|Argentina|Australia|Chile|United Kingdom 1
United States|Argentina|Austria|Belgium|Brazil|Canada|Czechia|France|Lithuania|Poland|Spain|Turkey 1
United States|Argentina|Belgium|Croatia|France|Germany|Greece|Italy|Korea, Republic of|Mexico|Puerto Rico|Romania|Russian Federation|Slovakia|Spain|Turkey 1
United States|Argentina|Canada|Mexico 1
United States|Argentina|Chile|Colombia|Mexico|Peru 1
United States|Argentina|Estonia|Finland|Russian Federation|Ukraine 1
United States|Argentina|Finland|France|Mexico|Sweden 1
United States|Argentina|Finland|Poland|Russian Federation 1
United States|Australia|Austria|Belgium|Germany|Sweden|United Kingdom 1
United States|Australia|Bulgaria|Canada|Germany|Hungary|Poland|Puerto Rico 1
United States|Australia|Canada 1
United States|Australia|Croatia|France|Germany|Korea, Republic of|Latvia|Lithuania|Malaysia|Netherlands|Poland|Russian Federation|Serbia|South Africa|Taiwan|Ukraine|United Kingdom 1
United States|Australia|Netherlands|New Zealand|South Africa 1
United States|Australia|Puerto Rico 1
United States|Belgium|Brazil|Bulgaria|France|Hungary|Italy|Poland|Spain 1
United States|Belgium|Czechia|Estonia|Finland|Germany|Hungary|Poland|Romania|South Africa|Sweden 1
United States|Belgium|Germany|Netherlands|United Kingdom 1
United States|Brazil|Chile|Lithuania|Mexico|Netherlands|Spain 1
United States|Bulgaria 1
United States|Bulgaria|Canada|Estonia|Finland|Germany|Korea, Republic of|Latvia|Lithuania|Mexico|Poland|Romania|Russian Federation|Sweden|Ukraine|United Kingdom 1
United States|Bulgaria|Canada|Puerto Rico|Romania|Russian Federation|Slovakia|United Kingdom 1
United States|Bulgaria|Estonia|Germany|Hungary|Korea, Republic of|Malaysia|Slovakia|South Africa|Spain|Taiwan 1
United States|Bulgaria|Estonia|Germany|Hungary|Ukraine 1
United States|Bulgaria|Estonia|Germany|Russian Federation 1
United States|Bulgaria|Finland|Germany|Romania|Russian Federation|Serbia|Ukraine 1
United States|Bulgaria|Finland|Poland 1
United States|Canada|Chile|Colombia|Croatia|Estonia|Finland|France|Latvia|Lithuania|Poland|Romania|Slovakia|South Africa 1
United States|Canada|Croatia|Mexico|Puerto Rico|Spain 1
United States|Canada|France|Germany|Hungary|Poland|Romania|Russian Federation|Serbia|Slovakia|Ukraine 1
United States|Canada|France|Germany|Israel 1
United States|Canada|France|Poland|Slovakia 1
United States|Canada|Germany|Hungary|Romania|Russian Federation|Ukraine 1
United States|Canada|Germany|Israel 1
United States|Canada|Germany|Puerto Rico 1
United States|Canada|Israel 1
United States|Canada|Italy 1
United States|Canada|Mexico 1
United States|Canada|Poland|Russian Federation|United Kingdom 1
United States|Chile 1
United States|Chile|Estonia|Germany|Korea, Republic of|Mexico|Russian Federation|South Africa 1
United States|Chile|Estonia|Russian Federation 1
United States|Chile|Germany|Japan|Mexico|Poland|Romania|Russian Federation|Taiwan 1
United States|Chile|Mexico 1
United States|Chile|Slovakia|South Africa 1
United States|Croatia|Czech Republic|France|Mexico|Russian Federation|Sweden|Turkey 1
United States|Croatia|Czechia|Finland|Japan|Puerto Rico|Slovakia 1
United States|Czechia|Finland|Germany|Greece|Israel|Poland|Russian Federation|Spain 1
United States|Czechia|Finland|Poland|Puerto Rico|Serbia|Slovakia 1
United States|Estonia|Finland|Former Serbia and Montenegro|France|Germany|Latvia|Lithuania|Poland|Slovakia|South Africa 1
United States|Estonia|Finland|Germany|Poland 1
United States|Estonia|Finland|Slovakia|Sweden|Ukraine 1
United States|Finland|Poland|Russian Federation|Serbia|Slovakia|Ukraine|United Kingdom 1
United States|France|Germany|Italy|Russian Federation|Sweden 1
United States|France|Germany|Puerto Rico|Romania|Sweden 1
United States|France|Germany|Russian Federation|Slovakia|South Africa|Ukraine 1
United States|France|Mexico|Puerto Rico 1
United States|Germany|Hungary|Poland|Slovakia 1
United States|Germany|Moldova, Republic of|Russian Federation|Ukraine|United Kingdom 1
United States|India|Puerto Rico 1
United States|Japan 1
United States|Japan|Latvia|Poland|Russian Federation|South Africa|Ukraine 1
United States|Moldova, Republic of|Russian Federation|Spain|Ukraine|United Kingdom 1
United States|Romania 1
United States|Russian Federation|Serbia|Ukraine|United Kingdom 1
United States|Taiwan 1

Sites per Study

Site_count Study_Count
1 755
2 70
3 12
4 19
5 13
6 14
7 10
8 11
9 14
10 4
11 4
12 7
13 9
14 9
15 9
16 6
17 4
18 4
19 6
20 6
21 6
22 6
23 7
24 7
25 8
26 4
27 4
28 2
29 2
31 4
32 6
33 4
34 6
35 7
36 2
37 5
38 5
39 2
40 3
41 2
42 2
43 7
44 8
45 4
46 2
47 5
48 2
49 3
50 3
51 4
52 1
53 3
54 2
56 5
57 2
58 2
59 2
60 2
61 4
62 2
63 3
65 1
66 2
67 1
68 1
69 1
70 3
71 2
72 2
73 2
74 3
75 1
76 2
77 1
78 2
79 2
82 1
85 2
87 1
89 1
90 1
92 3
93 1
94 1
98 1
99 1
101 2
106 1
107 1
117 1
124 1
128 1
136 1
137 1
144 1
158 1
168 1

Phase

Phase Study_Count
N/A 403
Phase 3 267
Phase 2 191
Phase 4 181
Phase 1 88
Phase 2/Phase 3 30
Phase 1/Phase 2 25
Early Phase 1 12

Number of Arms

Number_of_Arms Count_of_Studies
1 209
2 563
3 185
4 78
5 10
6 6
7 3
8 3
9 2
11 1
13 1
14 1
NA 135

Number of Updates

Count of Versions Count of Studies
1 93
2 119
3 128
4 104
5 129
6 88
7 85
8 92
9 58
10 41
11 41
12 28
13 24
14 25
15 15
16 19
17 8
18 5
19 2
20 4
21 6
22 3
23 8
24 3
25 2
26 5
27 7
28 4
29 4
30 3
31 9
33 3
35 3
36 1
37 4
39 2
40 2
42 2
43 1
45 1
47 1
48 1
56 1
57 1
59 1
61 1
62 1
64 1
66 1
75 1
77 2
116 1
163 2
182 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 9086 1104 8.230073
Contacts/Locations 4622 988 4.678138
Recruitment Status 1835 973 1.885920
Study Design 1404 875 1.604571
None (earliest Version on record) 1197 1197 1.000000
Outcome Measures 1103 667 1.653673
Sponsor/Collaborators 829 544 1.523897
Arms 781 522 1.496169
Interventions 781 522 1.496169
Eligibility 739 480 1.539583
Study Description 735 433 1.697460
Study Identification 704 468 1.504274
Oversight 455 367 1.239782
References 381 264 1.443182
Results 302 302 1.000000
Conditions 253 180 1.405556
More Information 229 154 1.487013
IPDSharing 129 122 1.057377
Results Submission Events 110 110 1.000000
Baseline Characteristics 91 82 1.109756
Reported Adverse Events 63 59 1.067797
Participant Flow 62 58 1.068966
Documents 60 55 1.090909
2020 Study Status 1 1 1.000000
Quality Control Review has not concludedReturned: April 10 1 1 1.000000

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 9.0000 6.0000 4.00000 12.00 5.0000 10.0000 8.0000 2.0000
1st Qu. 17.5000 37.0000 18.00000 25.00 36.0000 24.5000 200.0000 34.2500
Median 20.5000 68.0000 30.00000 42.00 102.0000 60.0000 414.0000 77.5000
Mean 266.4167 196.3017 44.97701 62.64 196.9048 145.8333 490.9432 266.7556
3rd Qu. 58.7500 133.0000 56.00000 65.00 251.0000 120.0000 600.0000 268.2500
Max. 2700.0000 17300.0000 260.00000 271.00 2530.0000 720.0000 6058.0000 8000.0000

Trial Group Type

group_type Group_Count
Experimental 1246
Active Comparator 468
Placebo Comparator 429
NA 135
No Intervention 93
Other 84
Sham Comparator 69

Intervention Model

intervention_model Study_Count
Parallel Assignment 814
Single Group Assignment 261
Crossover Assignment 79
Factorial Assignment 17
NA 17
Sequential Assignment 9

Primary Purpose

primary_purpose Study_Count
Treatment 1019
Basic Science 54
Other 32
Prevention 24
Health Services Research 19
Supportive Care 16
Diagnostic 14
NA 13
Screening 5
Educational/Counseling/Training 1

Observational Studies

Studies by Country

Country Study_Count
United States 78
NA 16
Canada 9
China 5
France 5
Spain 5
Denmark 4
Germany 4
United Kingdom 3
Greece 2
Switzerland 2
Austria|China|Hong Kong|Israel|Lebanon|Malaysia|Mexico|Philippines|Saudi Arabia|Singapore|Taiwan|Thailand|United Arab Emirates 1
Chile 1
Egypt 1
Hong Kong 1
Iran, Islamic Republic of 1
Israel 1
Italy 1
Korea, Republic of 1
Malaysia 1
Taiwan 1
United States|Canada|France|Italy 1

Sites per Study

Site_count Study_Count
1 111
2 13
3 3
5 4
8 1
10 2
20 1
22 1
25 1
27 1
29 1
44 1
48 1
55 1
57 1
106 1

Number of Updates

Count of Versions Count of Studies
1 9
2 24
3 19
4 15
5 19
6 8
7 12
8 9
9 3
10 1
11 1
12 1
13 1
14 3
15 1
17 2
18 1
21 2
26 1
27 1
31 2
38 1
45 1
49 1
60 1
62 1
143 1
144 1
159 1
167 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 1534 135 11.362963
Study Description 452 53 8.528302
Contacts/Locations 355 101 3.514851
Study Design 192 101 1.900990
Recruitment Status 158 106 1.490566
None (earliest Version on record) 144 144 1.000000
Eligibility 122 60 2.033333
Sponsor/Collaborators 80 54 1.481481
References 77 31 2.483871
Outcome Measures 59 41 1.439024
Study Identification 59 51 1.156863
Oversight 55 49 1.122449
Groups 43 34 1.264706
Interventions 43 34 1.264706
Conditions 19 18 1.055556
IPDSharing 10 9 1.111111
Results 10 10 1.000000
Documents 2 2 1.000000
Baseline Characteristics 1 1 1.000000
More Information 1 1 1.000000
Participant Flow 1 1 1.000000
Reported Adverse Events 1 1 1.000000
Results Submission Events 1 1 1.000000

Enrollment Metrics

Measure Observational
Min 1.000
1st Qu 55.000
Median 115.000
Mean 1284.943
3rd Qu 364.000
Max 48865.000

Observation Model

observational_model Study_Count
Cohort 43
NA 35
Case-Control 23
Case-Only 16
Case Control 16
Other 6
Ecologic or Community 3
Defined Population, Natural History 1
Family-Based 1

Time Perspective

time_perspective Study_Count
Prospective 66
Cross-Sectional 32
Retrospective 21
NA 20
Other 4
Cross-Sectional, Prospective 1

Registries

Studies by Country

Country Study_Count
NA 2
United States 2
Argentina 1
Canada 1
Denmark 1
Germany 1
Korea, Republic of 1
Poland 1

Sites per Study

Site_count Study_Count
1 9
8 1

Number of Updates

Count of Versions Count of Studies
1 2
2 1
3 2
5 1
6 1
7 2
12 1

Update History Change Type

Change Type Count_of_Changes Count_of_Studies ratio
Study Status 37 8 4.625000
Contacts/Locations 11 6 1.833333
None (earliest Version on record) 10 10 1.000000
Recruitment Status 9 7 1.285714
Study Design 5 4 1.250000
Outcome Measures 3 2 1.500000
Eligibility 2 1 2.000000
Sponsor/Collaborators 2 1 2.000000
Study Description 2 2 1.000000
Groups 1 1 1.000000
Interventions 1 1 1.000000
Oversight 1 1 1.000000
References 1 1 1.000000
Study Identification 1 1 1.000000

Enrollment Metrics

Measure Registries
Min 40.00
1st Qu 71.25
Median 155.00
Mean 728.10
3rd Qu 275.00
Max 5716.00

Registry Model

observational_model Study_Count
Cohort 8
Case-Control 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 8
Cross-Sectional 1
Other 1

Follow-up

target_duration Study_Count
6 Months 2
1 Month 1
1 Week 1
1 Year 1
12 Months 1
12 Weeks 1
2 Weeks 1
3 Months 1
3 Years 1